FIBRINOLYSIS. ITS MECHANISM AND SIGNIFICANCE

Fibrinolysis; its mechanism and significance.

INTRODUCTION T HE BIOLOGIC processes that produce a gross physical change have always attracted much interest. The transformation of fluid blood to solid clot, for instance, has been the subject of experiment and discussion the amount of which seems disproportionate to its fundamental physiologic importance. There is, however , a converse to this process of coagulation which, though equally obv...

Lipid peroxidation: its mechanism, measurement, and significance.

An increased concentration of end products of lipid peroxidation is the evidence most frequently quoted for the involvement of free radicals in human disease. However, it is likely that increased oxidative damage occurs in most, if not all, human diseases and plays a significant pathological role in only some of them. For example, peroxidation appears to be important in atherosclerosis and in w...

Significance of intravascular coagulation and fibrinolysis in acute hepatic failure.

Twenty-two patients with acute hepatic failure were studied to determine the incidence and magnitude of intravascular coagulation and fibrinolysis and their relation to the severity of bleeding and prognosis. The mean platelet count, Thrombotest, plasminogen activator, and plasminogen were reduced; the reduction in fibrinogen was not statistically significant. Fibrin/fibrinogen degradation prod...

Defective fibrinolysis in Behçet's syndrome: significance and possible mechanisms.

Reduced fibrinolytic activity has frequently been reported in Behcet's syndrome, but both the underlying mechanism and its relation to the development of thrombosis are unclear. The fibrinolytic activity was studied in seven patients with Behçet's syndrome and 12 patients with idiopathic oral ulceration. The patients with Behçet's disease had significantly reduced resting tissue plasminogen act...

Proteolysis, fibrinolysis, and coagulation. Significance in thrombolytic therapy.